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A breath of fresh air

Transforming lives by treating diseases caused by epithelial dysfunction.

We are a clinical-stage biopharmaceutical company with a unique approach to developing drugs for chronic inflammatory diseases, focusing on enhancing the epithelium.

About epithelial dysfunction and EP395

The Connection Between the Epithelium and Lung Inflammation

EpiEndo Pharmaceuticals is founded on the hypothesis that acute exacerbations of chronic airway diseases (CADs) are primarily triggered by insults to the epithelial barrier of the airways. As a result, EpiEndo Pharmaceuticals aims to expand the therapeutic and diagnostic approaches for CADs beyond bronchoconstriction and inflammation.

Epithelial cells are a key part of the barrier that makes up human lung tissue and other organs. Damage of this barrier is implicated in several chronic inflammatory conditions, including COPD and other lung diseases. By enhancing the epithelium and reducing inflammation, our lead compound, EP395, aims to slow disease progression.

A Promising Solution for COPD Patients

COPD is the third largest cause of death globally, causing irreversible airflow obstruction. EP395, an oral barrier-enhancing and anti-inflammatory drug, which has the potential to be a unique and impactful treatment option for COPD patients.

4.8trn
is the global economic burden of COPD by 2030
3rd
COPD is leading cause of death globally
20bn+
COPD therapeutic market size by 2026

Developing First-in-Class Drugs to Address Chronic Respiratory Diseases

Our new class of oral drugs, known as Barriolides™, have the potential to be first-in-class therapies for respiratory diseases and beyond.

We have a unique approach to developing drugs for chronic inflammatory diseases, based on over 20 years of research into macrolides and their effects on the lung epithelium. The central focus of our pathophysiological models is on the acute immune response of the bronchial epithelial barrier, emphasising its breakdown, maladaptation, and dysfunction caused by persistent or overwhelming injury to the airway's mucosal lining.

This shift in perspective establishes a new theoretical basis for understanding, diagnosing, and treating CADs as epithelial diseases, rather than considering them solely as inflammatory diseases.

Empowering a healthier future with an innovative approach - we are working to transform lives by treating diseases caused by epithelial dysfunction with our first-in-class, oral Barriolides™

Our Team

Dedicated Experts

We are led by a passionate and highly experienced team with deep scientific knowledge and clinical and pharmaceutical industry expertise. Our team of dedicated professionals is committed to making a difference in the lives of respiratory disease patients.
Chief Executive Officer
Chief Financial Officer
Chief Medical Officer
Chief Operating Officer
Director of Research
Chairman of the Board
Board Member
Board Member
Board Member
Board Member
Board Member
Board Member
SAB
SAB
SAB
SAB
SAB
SAB
SAB
SAB
SAB
SAB

News & Events

07 May 2024
REYKJAVIK, ICELAND – 7 May 2024 – EpiEndo Pharmaceuticals (‘EpiEndo’ or the ‘Company’), a clinical-stage biopharmaceutical company developing a new class of oral, barrier-enhancing, anti-inflammatory therapeutics addressing chronic airway diseases, has contributed to a book chapter in Macrolides as Immunomodulatory Agents, published in January.
10 Apr 2024
REYKJAVIK, ICELAND – 10 April 2024 – EpiEndo Pharmaceuticals (‘EpiEndo’ or the ‘Company’), a clinical-stage biopharmaceutical company developing a new class of oral, barrier-enhancing, anti-inflammatory therapeutics addressing chronic airway diseases, announces the successful completion of its Phase 2A clinical trial for EP395 in patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD).
30 Jan 2024
EpiEndo Pharmaceuticals has announced the recent appointments of Professor Bartolome Celli and Professor Fernando J. Martinez to its Scientific Advisory Board.
24 Jan 2024
EpiEndo Pharmaceuticals is pleased to be celebrating its 10-year anniversary today.
Sustainability

EpiEndo's Commitment to a Better Future

We are committed to sustainability and to minimizing our environmental impact and we are working towards formalizing our ESG policies. We measure ourselves against the United Nations Sustainable Development Goals and have implemented internal goals and policies that align with these goals.

Our key pillars

Ensure healthy lives and promote well-being for all at all ages

EpiEndo aims to improve the quality of life of people with chronic diseases caused by epithelial dysfunction.

Promote inclusive and sustainable economic growth, employment and decent work for all

EpiEndo is committed to having an inclusive work culture with a healthy balance between work and private life.

Build resilient infrastructure, promote sustainable industrialization and foster innovation

EpiEndo, through its collaborative way of working, will continue to innovate and expand the life-science industry in Iceland.

Ensure sustainable consumption and production patterns

EpiEndo works towards responsible consumption and production internally and externally.

Our values

At EpiEndo, we are dedicated to conducting our business with integrity and upholding the highest ethical standards. Our code of conduct sets the standard for our employees, partners, and suppliers, and outlines our commitment to ethical behavior, compliance with laws and regulations, and respect for the rights and dignity of all individuals. Our code of conduct reflects our values and our commitment to conducting business with the highest level of professionalism and ethical standards.